Plant-based bio-lubricant is crucial to be developed and adopted by many industries. This is due to the presence of toxicity risk, climate change, energy security as well greenenvironmental approach issues. The utilization of palm oil processing industries' by-product, palm fatty acid distillate (PFAD-based bio-lubricants is one way of a green environment approach. A synthesis of polyol esters based on PFAD for bio-lubricants was carried out. The esterification of PFAD with high-degree polyhydric alcohols trimethylolpropane (TMP), di-trimethylopropane (di-TMP), pentaerythritol (PE), and di-pentaerythritol (Di-PE) in the presence of sulphuric acid (H2SO4) catalyst have been performed. The optimization of the esterification reaction process was evaluated using a D-optimal design based on three reaction parameters,H2SO4 concentration (%) for the catalyst, esterification time (h), and esterification temperature (°, C). The chemical structure of the synthesized polyol esters was characterized and confirmed by using FT-IR and NMR (1H and 13C) spectroscopies. The results showed that PFAD-based polyesters of PFAD-TMP ester successfully produced high yields of 93% compared to others. The synthesized PFAD-based polyesters showed good lubrication properties with high viscosity indices in the range of 141-187, pour points (-5 to 5 º, C), flash points (230-360 º, C), and oxidative stability temperature (188-301 °, C), respectively. The ester functional group present in the chemical structure of PFAD-based polyesters showed a positive impact on the lubrication properties. The study indicated that PFAD-based polyesters are plausible to be used in industrial bio-lubricant applications.